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Researchers at Johns Hopkins University invented a “cellular switch” that let cancer cells produce their own cancer medication and cause the cancer cells to self-destruct while sparing healthy tissue.
“The switch in effect turns the cancer cell into a factory for producing the anti-cancer drug inside the cancer cell,” said Marc Ostermeier, a Johns Hopkins chemical and biomolecular engineering professor in the Whiting School of Engineering, who supervised development of the switch. “The healthy cells will also receive the prodrug and ideally it will remain in its non-toxic form. Our hope is that this strategy will kill more cancer cells while decreasing the unfortunate side effects on healthy cells.”
The research team made the cancer-fighting switch by fusing together two different proteins; one that detects a marker that cancer cells produce and another protein extracted from yeast that can turn an inactive prodrug into a cancer-cell killer.
“When the first part of the switch detects cancer, it tells its partner to activate the chemotherapy drug, destroying the cell,”
“This is a radically different tool to attack cancers,” said James R. Eshleman, a professor of pathology and oncology in the Johns Hopkins School of Medicine and a co-author of the paper that appears in the Proceedings of the National Academy of Sciences, “but many experiments need to be done before we will be able to use it in patients.”
Researchers have discovered how a high fat diet contributes to prostate disease and cancer. Findings from Case Western Reserve University researchers show that a high fat diet triggers a protein that controls DNA and leads to inflammation and prostate diseases. The discovery showing how a high fat diet can lead to prostate cancer, prostatitis and benign prostatic hypertrophy (BPH) explain the possible link between a high fat diet and prostate diseases.
Prostate cancer is the second leading cause of cancer deaths in men. Dietary factors have consistently been shown to increase the chances of developing the disease. Researchers found that fat triggers the protein complex that controls DNA transcription. The protein is activated in response to stress and inflammation brought about by consuming foods high in fat.
The most common prostate problems experienced by men are prostatitis and enlargement of the prostate (BPH). When researchers fed mice high fat diet and compared the mice to a control group given low fat diet they discovered how fat affects the prostate gland.
Markers of oxidative stress were measured in the prostate cells of the mice, providing direct evidence that a high fat diet triggers the protein complex nuclear factor kappa B, setting off a chain reaction. The result of a high fat diet was increased weight of the prostate gland, cell proliferation that leads to BPH and inflammation.
Certainly too much for me …
A new study in Japan, appearing in the Annals of Epidemiology, shows that drinking seven cups of green tea a day could cut heart disease risk death by a massive 75%.
The study followed over 12,000 people between the ages of 65 and 84 over five years. In comparison to people who drink less than one cup of green tea per day, those who drink seven show, in addition to the impressive heart benefits, a 55% lower risk of death from other diseases.
For example: Their risk of death from colorecta cancer shows a massive 31% drop.
Now, the researchers say these strong effects may be due to a lifetime of heavy green tea drinking.
But, given all of the other benefits of green tea – protection against Alzheimer’s, lower risk of prostate cancer, and help with weight loss – I say there’s no such thing as “too late” for green tea.
Especially when you look at some recent work at the Chinese University of Hong Kong. There, scientists have reported the cells of regular tea drinkers (an average of 3 cups per day) may actually have a younger biological age than the cells of people who don’t drink tea. At the Chinese University of Hong Kong. There, scientists have reported the cells of regular tea drinkers (an average of 3 cups per day) may actually have a younger biological age than the cells of people who don’t drink tea.
By Maggie Fox
WASHINGTON — Pancreatic tumor cells use fructose to divide and proliferate, U.S. researchers said on Monday in a study that challenges the common wisdom that all sugars are the same.
Tumor cells fed both glucose and fructose used the two sugars in two different ways, the team at the University of California Los Angeles found.
They said their finding, published in the journal Cancer Research, may help explain other studies that have linked fructose intake with pancreatic cancer, one of the deadliest cancer types. (more…)